![]() ![]() Division of Public Health, Surveillance and Response.Centre for Respiratory Diseases and Meningitis.Centre for Healthcare-Associated Infections, Antimicrobial Resistance and Mycoses.Centre for Emerging Zoonotic and Parasitic Diseases.COVID-19 Vaccine Breakthrough Cases Frequently Asked Questions.She's open to getting the vaccine again if health authorities suggest it for subsequent pregnancies, she said. Zangrilli said Harrison is now 18 months old and has not tested positive for RSV thus far. Health authorities have not yet weighed in on whether pregnant mothers who plan to immunize their babies with Beyfortus should get the Abrysvo vaccine, but it may be a topic of discussion for the CDC's advisory committee. But no data directly comparing the two exists yet. That may lower the chances that RSV escapes immunity from the vaccine relative to the antibody shot. Gruber said Abrysvo might produce a broader antibody response, however, since the process the vaccine spurs is closer to how the body would naturally defend itself against a virus. It’s also recommended for infants 8 to 19 months old who are at increased risk of severe disease and entering their second season. The antibody injection, called Beyfortus, is CDC-recommended for babies up to 8 months old who are born during or entering their first RSV season, which typically starts around October. Unlike past RSV seasons, expectant parents and those with young babies now have two ways to protect their children. Two new options for infants: A vaccine and an antibody drug “Whether it’s pertussis, influenza, tetanus, there’s a long track record of safety for administering vaccines to pregnant women," Gruber said. She gave birth to her son, Harrison, when he was full term. ![]() Trial participants weren't told whether they received the vaccine or a placebo, but Zangrilli said she didn’t experience any side effects. Pfizer has said it will continue to monitor the risk of preterm birth among vaccine recipients. Both of those observed rates were lower than the rate of preterm births in the general population: around 10%, according to the CDC. ![]() In the trial, there was a slightly higher rate of births before 37 weeks’ gestation among people who got the vaccine (5.7%) than among those who got a placebo (4.7%).Īlthough the difference wasn’t statistically significant, the prescribing label for the vaccine will come with a warning not to administer Abrysvo before 32 weeks' gestation because of that numerical imbalance. In May, an FDA advisory committee reviewed data on the vaccine, and though the group generally praised its efficacy, there were some reservations about the duration of protection and a potential risk of preterm birth. ![]() The most common side effects reported among pregnant women who got the shot were fatigue, headache, injection site pain, muscle pain, nausea, joint pain and diarrhea. Ultimately, she said, her worry about her baby getting RSV won out. My husband and I spent like three days just deciding on whether or not we wanted to do it,” Zangrilli said. Still, she said she thought carefully about whether to get an experimental vaccine. Zangrilli works as an operations coordinator at Children’s Hospital Colorado and was aware of the health risks of RSV among infants. Tamara Zangrilli was among the first people to take Abrysvo while pregnant - she signed up for Pfizer's clinical trial in 2021. Strong protection against severe disease - but for how long? According to a study published this month, most babies who ended up in the intensive care unit with RSV in late 2022 were previously healthy and born full term. Last year’s RSV season brought a dramatic spike in severe illness that overwhelmed children’s hospitals. and up to 160,000 hospitalizations among people 65 and up. In serious cases, however, an infection can lead to pneumonia or bronchiolitis, which inflames airways and clogs them with mucus. Older adults and babies are particularly susceptible: RSV leads to up to 300 deaths a year among those under 5 in the U.S. RSV overall is mild, and most children have been infected by age 2. ![]()
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